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Can I read Gymnemic Acid Ameliorates Pancreatic β-Cell Dysfunction by Modulating Pdx1 Expression: A Possible Strategy for β-Cell Regeneration on EtoBox?
Gymnemic Acid Ameliorates Pancreatic β-Cell Dysfunction by Modulating Pdx1 Expression: A Possible Strategy for β-Cell Regeneration by Pugazhendhi Kannan; Malathi Raghunathan; Thangarajeswari Mohan; Shanthi Palanivelu; Kalaiselvi Periandavan is a Medicine article available to read on EtoBox.
What is Gymnemic Acid Ameliorates Pancreatic β-Cell Dysfunction by Modulating Pdx1 Expression: A Possible Strategy for β-Cell Regeneration about?
BACKGROUND: Endogenous pancreatic b-cell regeneration is a promising therapeutic approach for enhancing b-cell function and neogenesis in diabetes. Various findings have reported that regeneration might occur via stimulating b-cell proliferation, neogenesis, or conversion from other pancreatic cells to b-like cells. Although the current scenario illustrates numerous therapeutic strategies and approaches that concern endogenous b-cell regeneration, all of them have not been successful to a greater extent because of cost effectiveness, availability of suitable donors and rejection in case of transplantation, or lack of scientific evidence for many phytochemicals derived from plants that have been employed in traditional medicine. Therefore, the present study aims to investigate the effect of gymnemic acid (GA) on b-cell regeneration in streptozotocin-induced type 1 diabetic rats and high glucose exposed RIN5-F cells. METHODS: The study involves histopathological and immunohistochemical analysis to examine the islet's architecture. Quantitative polymerase chain reaction (qPCR) and/or immunoblot were employed to quantify the b-cell regeneration markers and cell cycle proliferative mark
Who reads Gymnemic Acid Ameliorates Pancreatic β-Cell Dysfunction by Modulating Pdx1 Expression: A Possible Strategy for β-Cell Regeneration?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Pugazhendhi Kannan; Malathi Raghunathan; Thangarajeswari Mohan; Shanthi Palanivelu; Kalaiselvi Periandavan
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)