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Does Antiplatelet Therapy during Bridging Thrombolysis Increase Rates of Intracerebral Hemorrhage in Stroke Patients? by Anne Broeg-Morvay; Pasquale Mordasini; Agnieszka Slezak; Kai Liesirova; Julia Meisterernst; Gerhard Schroth; Marcel Arnold; Simon Jung; Heinrich P. Mattle; Jan Gralla; Urs Fischer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Does Antiplatelet Therapy during Bridging Thrombolysis Increase Rates of Intracerebral Hemorrhage in Stroke Patients? about?
## Background: Symptomatic intracerebral hemorrhage (sich) after bridging thrombolysis for acute ischemic stroke is a devastating complication. we aimed to assess whether the additional administration of aspirin during endovascular intervention increases bleeding rates. ## Methods: We retrospectively compared bleeding complications and outcome in stroke patients who received bridging thrombolysis with (tpa+asa) and without (tpa-asa) aspirin during endovascular intervention between november 2008 and march 2014. furthermore, we analyzed bleeding complications and outcome in antiplatelet naïve patients with those with prior or acute antiplatelet therapy. ## Results: Baseline characteristics, previous medication, and dosage of rtpa did not differ between 50 tpa+asa (39 aspirin naïve, 11 preloaded) and 181 tpa-asa patients (p>0.05). tpa+asa patients had more often internal carotid artery (ica) occlusion (p<0.001), large artery disease (p<0.001) and received more often acute stenting of the ica (p 0.1). there were no differences in bleeding complications and mortality among 112 bridging patients with antiplatelet therapy (62 preloaded, 39 acute administration, 11 both) and 117 antiplatel
Who reads Does Antiplatelet Therapy during Bridging Thrombolysis Increase Rates of Intracerebral Hemorrhage in Stroke Patients??
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Anne Broeg-Morvay; Pasquale Mordasini; Agnieszka Slezak; Kai Liesirova; Julia Meisterernst; Gerhard Schroth; Marcel Arnold; Simon Jung; Heinrich P. Mattle; Jan Gralla; Urs Fischer
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)