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Pharmacokinetic and Pharmacodynamic Interactions Between Diltiazem and Quinidine* by Laganière, Sylvie; Davies, Richard F.; Carignan, Germain; Foris, Kathy; Goernert, Lynne; Carrier, Karen; Pereira, Conrad; McGilveray, Iain is a Medicine article available to read on EtoBox.

What is Pharmacokinetic and Pharmacodynamic Interactions Between Diltiazem and Quinidine* about?

Objectives: To examine the pharmacokinetic and pharmacodynamic interactions between quinidine and diltiazem because both drugs can inhibit drug metabolism. Methods: Twelve fasting, healthy male volunteers (age, 24 rt 5 years; weight, 75 + 10 kg) received a single oral dose of diltiazem (60 mg) or quinidine (200 mg), alone and on a background of the other drug, in a crossover study. Background treatment consisted of 100 mg quinidine twice a day or 90 mg sustainedrelease diltiazem twice a day for 2 days before the study day. Res~Zts: Pretreatment with diltiazem significantly (p < 0.05) increased the area under the curve of quinidine from 7414 + 1965 to 11,213 f 2610 ng \* hr/ml and increased its terminal elimination half-life (t& from 6.8 f 1.1 to 9.3 + 1.5 hours. Its oral clearance was decreased from 0.39 +-0.1 to 0.25 f 0.1 L/hr/kg, whereas the maximal concentration was not significantly affected. Diltiazem disposition was not significantly affected by pretreatment with quit&line. Diltiazem pretreatment increased QT, and PR intervals and decreased heart rate and diastolic blood pressure. No significant pharmacodynamic differences were shown for diltiazem alone versus quinidine pret

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Author

Laganière, Sylvie; Davies, Richard F.; Carignan, Germain; Foris, Kathy; Goernert, Lynne; Carrier, Karen; Pereira, Conrad; McGilveray, Iain

Publisher

Nature Publishing Group; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley; Springer Science and Business Media LLC; Research Square (ISSN 0009-9236)

Published

1996

Language

EN

Field

Medicine (Health Sciences)