Can I read Intestinal Dysbiosis in, and Enteral Bacterial Therapies for, Systemic Autoimmune Diseases on EtoBox?

Intestinal Dysbiosis in, and Enteral Bacterial Therapies for, Systemic Autoimmune Diseases by Marietta, Eric; Mangalam, Ashutosh K.; Taneja, Veena; Murray, Joseph A. is a Immunology and Microbiology article available to read on EtoBox.

What is Intestinal Dysbiosis in, and Enteral Bacterial Therapies for, Systemic Autoimmune Diseases about?

Recent studies have shown that a number of common autoimmune diseases have perturbations of their intestinal microbiome (dysbiosis). These include: Celiac Disease (CeD), Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), Sjogren's Syndrome (SS), and Type 1 diabetes (T1D). All of these have intestinal microbiomes that are different from healthy controls. There have been numerous studies using animal models of single probiotics (monoclonal) or mixtures of probiotics (polyclonal) and even complete microbiota transfer (fecal microbial transfer-FMT) to inhibit or delay the onset of autoimmune diseases such as the aforementioned common ones. However, proportionally, fewer clinical trials have utilized monoclonal therapies or FMT than polyclonal therapies for treating autoimmune diseases, even though bacterial mono-therapies do inhibit the development of autoimmune diseases and/or delay the onset of autoimmune diseases in rodent models of those autoimmune diseases. In this review then, we review the previously completed and currently ongoing clinical trials that are testing bacterial therapies (FMT, monoclonal, and polyclonal) to treat common autoimmune dseases and discuss the successes

Who reads Intestinal Dysbiosis in, and Enteral Bacterial Therapies for, Systemic Autoimmune Diseases?

Author

Marietta, Eric; Mangalam, Ashutosh K.; Taneja, Veena; Murray, Joseph A.

Publisher

Frontiers; Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2010- (ISSN 1664-3224)

Published

2020

Language

EN

Field

Immunology and Microbiology (Life Sciences)