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Characterizing Long COVID: Deep Phenotype of a Complex Condition by Rachel R Deer; Madeline A Rock; Nicole Vasilevsky; Leigh Carmody; Halie Rando; Alfred J Anzalone; Tiffany J Callahan; Carolyn T Bramante; Christopher G Chute; Casey S Greene; Joel Gagnier; Haitao Chu; Farrukh M Koraishy; Chen Liang; Feifan Liu; Charisse R Madlock-Brown; Diego R Mazzotti; Douglas S McNair; Ann M Parker; Ben D Coleman; Hannah E Davis; Mallory A Perry; Justin T Reese; Joel Saltz; Anthony E Solomonides; Anupam A Sule; Gary S Stein; Sebastian Köhler; Teshamae S Monteith; Vithal Madhira; Wesley D Kimble; Ramakanth Kavuluru; William B Hillegass; Lauren E Chan; James Brian Byrd; Eilis A Boudreau; Hongfang Liu; Julie A McMurry; Emily Pfaff; Nicolas Matentzoglu; Rose Relevo; Richard A Moffitt; Robert A Schuff; Julian Solway; Heidi Spratt; Timothy Bergquist; Tellen D Bennett; Marc D Basson; Umit Topaloglu; Liwei Wang; Melissa A Haendel; Peter N Robinson is a scholarly article available to read on EtoBox.

What is Characterizing Long COVID: Deep Phenotype of a Complex Condition about?

## ABSTRACT ## Importance Since late 2019, the novel coronavirus SARS-CoV-2 has given rise to a global pandemic and introduced many health challenges with economic, social, and political consequences. In addition to a complex acute presentation that can affect multiple organ systems, there is mounting evidence of various persistent long-term sequelae. The worldwide scientific community is characterizing a diverse range of seemingly common long-term outcomes associated with SARS-CoV-2 infection, but the underlying assumptions in these studies vary widely making comparisons difficult. Numerous publications describe the clinical manifestations of post-acute sequelae of SARS-CoV-2 infection (PASC or “long COVID”), but they are difficult to integrate because of heterogeneous methods and the lack of a standard for denoting the many phenotypic manifestations of long COVID. ## Observations We identified 303 articles published before April 29, 2021, curated 59 relevant manuscripts that described clinical manifestations in 81 cohorts of individuals three weeks or more following acute COVID-19, and mapped 287 unique clinical findings to Human Phenotype Ontology (HPO) terms. ## Conclusions and

Author

Rachel R Deer; Madeline A Rock; Nicole Vasilevsky; Leigh Carmody; Halie Rando; Alfred J Anzalone; Tiffany J Callahan; Carolyn T Bramante; Christopher G Chute; Casey S Greene; Joel Gagnier; Haitao Chu; Farrukh M Koraishy; Chen Liang; Feifan Liu; Charisse R Madlock-Brown; Diego R Mazzotti; Douglas S McNair; Ann M Parker; Ben D Coleman; Hannah E Davis; Mallory A Perry; Justin T Reese; Joel Saltz; Anthony E Solomonides; Anupam A Sule; Gary S Stein; Sebastian Köhler; Teshamae S Monteith; Vithal Madhira; Wesley D Kimble; Ramakanth Kavuluru; William B Hillegass; Lauren E Chan; James Brian Byrd; Eilis A Boudreau; Hongfang Liu; Julie A McMurry; Emily Pfaff; Nicolas Matentzoglu; Rose Relevo; Richard A Moffitt; Robert A Schuff; Julian Solway; Heidi Spratt; Timothy Bergquist; Tellen D Bennett; Marc D Basson; Umit Topaloglu; Liwei Wang; Melissa A Haendel; Peter N Robinson

Publisher

Cold Spring Harbor Laboratory

Published

2021

Language

EN