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Distribution and Origin of Vesicular Glutamate Transporter 2‐Immunoreactive Fibers in the Rat Hippocampus by Katalin Halasy; Tibor Hajszan; Éva G. Kovács; Thien‐Tri Lam; Csaba Leranth is a Neuroscience article available to read on EtoBox.

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## Abstract This study examined the distribution of vesicular glutamate transporter 2 (VGLUT2)‐immunoreactive neuronal structures in the ipsilateral and contralateral hippocampi of unilateral fimbria/fornix transected, unilateral entorhinal cortex ablated, and intact female and male rats. In the hippocampi of intact animals, the highest density of VGLUT2‐positive boutons was observed in the supragranular layer of the dentate gyrus, followed by the CA2 pyramidal and oriens layers, and the stratum lacunosum‐moleculare of the CA1 field. This staining pattern was identical both in males and in females. Electron microscopic examination revealed that the immunolabeling was confined to axon terminals forming exclusively asymmetric synaptic contacts. The quantitative analysis of the synaptic targets of VGLUT2‐positive terminals showed that in the dentate gyrus, 59% of the synaptic targets were dendritic spines, followed by dendritic shafts (22%) and granule cell somata (19%). In the pyramidal layer of the CA2 field, VGLUT2‐immunoreactive boutons contacted mostly dendritic shafts (85%), only some of which (15%) synapsed with spines. The synaptic targets of VGLUT2‐positive varicosities were

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Author

Katalin Halasy; Tibor Hajszan; Éva G. Kovács; Thien‐Tri Lam; Csaba Leranth

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)

Published

2004

Language

EN

Field

Neuroscience (Life Sciences)