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Role of protein tyrosine phosphatases in T cell activation by Tomas Mustelin; Souad Rahmouni; Nunzio Bottini; Andres Alonso is a Immunology and Microbiology article available to read on EtoBox.

What is Role of protein tyrosine phosphatases in T cell activation about?

## Summary: The last decade has seen an exponentially increasing interest in the molecular mechanisms of signal transduction. In T cells, much of the focus has been on protein tyrosine kinase (PTK)‐mediated signaling from the T cell receptor (TCR) and cytokine receptors, while the study of protein tyrosine phosphatases (PTPases) has lagged behind. However, recent discoveries have revealed that several PTPases play important roles in many different aspects of T cell physiology. We predict that the phosphatases will become a ‘hot topic’ in the field within the next few years. This review summarizes the current understanding of the regulation and biology of PTPases in T lymphocyte activation.

Who reads Role of protein tyrosine phosphatases in T cell activation?

Author

Tomas Mustelin; Souad Rahmouni; Nunzio Bottini; Andres Alonso

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0105-2896)

Published

2003

Language

EN

Field

Immunology and Microbiology (Life Sciences)