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p53 mutation profile of squamous cell carcinomas of the esophagus in Kashmir (India): A high‐incidence area by Mohammad Muzaffar Mir; Nazir Ahmad Dar; Sailesh Gochhait; Showkat Ali Zargar; Abdul Gani Ahangar; R.N.K. Bamezai is a Medicine article available to read on EtoBox.

What is p53 mutation profile of squamous cell carcinomas of the esophagus in Kashmir (India): A high‐incidence area about?

## Abstract Esophageal squamous cell carcinoma (ESCC) has been reported to show geographical variation in its incidence, even within areas of ethnic homogeneity. Kashmir valley, in north of India, has been described as a high‐risk area for ESCC. Here, we make a preliminary attempt to study mutations in exons 5–8 (the DNA binding domain) of the tumor suppressor gene, __p53__, in 55 ESCC patients from Kashmir. Polymerase chain reaction followed by direct sequencing analysis revealed the presence of mutations in 36.36% (20/55) tumors, assessed for the extent of allelic instability. The 20 mutations, found in 20 patients, comprised of 17 single‐base substitutions (11 transitions + 6 transversions) and 3 deletions. The 17 single‐base variations represented 12 missense mutations, 2 nonsense mutations and 3 variations located in intron 6, 1 of which resulted in a splicing variant. The patients when compared for the incidence of __p53__ mutation with various demographic features revealed females to be at increased risk (__p__ = 0.016; OR = 4.13; 95% CI = 1.26–13.46). Comparison of mutation profile with other high‐risk areas reflected both differences and similarities indicating coexposure

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Author

Mohammad Muzaffar Mir; Nazir Ahmad Dar; Sailesh Gochhait; Showkat Ali Zargar; Abdul Gani Ahangar; R.N.K. Bamezai

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2005

Language

EN

Field

Medicine (Health Sciences)