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Prevalence of frailty and prediction of mortality in Chinese cancer patients using a frailty index‐based clinical algorithm—A multicentre study by Jin, Xi (author);Ren, Yue (author);Shao, Li (author);Guo, Zengqing (author);Wang, Chang (author);He, Ying (author);Zhou, Lan (author);Cong, Minghua (author);Ma, Hu (author);Wang, Wei (author);Zhou, Chunling (author);Feng, Yongdong (author);Ba, Yi (author);Gao, Jianguo (author);Lu, Miaomiao (author);Zhang, Mengmeng (author);Gu, Xue‐wei (author);Song, Chunhua (author);Xu, Hongxia (author);Shi, Hanping (author) is a Medicine article available to read on EtoBox.

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## Abstract ## Purpose To investigate the frailty status in Chinese cancer patients through establishing a novel prediction algorithm. ## Methods The percentage of frailty in various age groups, locations, and tumor types in Chinese cancer patients was investigated. The prediction capacity of frailty on mortality of Chinese cancer patients was analysed by the frailty index composing of routine laboratory data (FI‐LAB) accessible from a blood test and calculated as the ratio of abnormal factors to 22 total variables. The establishment of a novel algorithm, MCP (mortality of cancer patients), to predict the 5‐year mortality in Chinese cancer patients was accomplished and the algorithm's prediction capacity was tested in the training and validation sets using receiver operating characteristic (ROC) analysis. ## Results We found that the risk of death in cancer patients can be successfully identified through FI‐LAB. The univariable and multivariable Cox regression were used to evaluate the effect of frailty on death. In the 5‐year follow‐up, 20.6% of the 2959 participants (age = 55.8 ± 11.7 years; 43.5% female) died, while the mean FI‐LAB score in baseline was 0.23 (standard deviation

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Author

Jin, Xi (author);Ren, Yue (author);Shao, Li (author);Guo, Zengqing (author);Wang, Chang (author);He, Ying (author);Zhou, Lan (author);Cong, Minghua (author);Ma, Hu (author);Wang, Wei (author);Zhou, Chunling (author);Feng, Yongdong (author);Ba, Yi (author);Gao, Jianguo (author);Lu, Miaomiao (author);Zhang, Mengmeng (author);Gu, Xue‐wei (author);Song, Chunhua (author);Xu, Hongxia (author);Shi, Hanping (author)

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)