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Radiotherapeutic Parameters Predictive of Liver Complications Induced by Liver Tumor Radiotherapy by Ik Jae Lee; Jinsil Seong; Su Jung Shim; Kwang Hyub Han is a Medicine article available to read on EtoBox.

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Purpose: The purpose of this study was to identify radiotherapeutic parameters for predicting the occurrence of liver complications induced by radiotherapy of a liver tumor. Methods and Materials: From 2001 to 2003, a total of 131 patients with hepatocellular carcinoma received threedimensional conformal radiotherapy. The total dose was determined by the fraction of nontumor liver receiving 50% of the isocenter dose (V 50% ). We evaluated three sets of published radiation dose guidelines using nontumor liver volume or a combination of nontumor liver volume and hepatic functional reserve. The V 50% was divided into three intervals ( 66%) and four categories ( 75%) according to guidelines by the University of Michigan and the Yonsei University, respectively. According to the guideline of Cheng et al., the radiation dose was determined by the indocyanin green retention rate at 15 min (ICG-R15) and the nontumor liver volume. Results: Of the 131 patients, 13 patients (9.9%) presented with liver complications. The incidence was 11.1%, 10.3%, and 18.2%, respectively, for a V 50% of less than 33%, 33% to 66%, and more than 66%. The observed hepatic toxicity incidence was 10%, 12.1%, and 10

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Author

Ik Jae Lee; Jinsil Seong; Su Jung Shim; Kwang Hyub Han

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2009

Language

EN

Field

Medicine (Health Sciences)