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Fos Imaging Reveals Ageing‐related Changes in Hippocampal Response to Radial Maze Discrimination Testing in Mice by Khalid Touzani; Aline Marighetto; Robert Jaffard is a Neuroscience article available to read on EtoBox.

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## Abstract A two‐stage radial arm maze (RAM) task has been designed recently to demonstrate a specific age‐related memory deficit in mice. It highlights the contrast between normal and deficient memory expression in a spatial discrimination problem depending on how to‐be discriminated arms were presented to the animal. This specific deficit has been interpreted as a preferential loss in a relational/declarative form of memory, thereby implying an underlying hippocampal dysfunction. To test this hypothesis, neuronal activation measured by Fos immunostaining was compared in aged (21–23 months) and adult (4–6 months) mice trained in the aforementioned task and killed after a retention session consisting in age‐insensitive probe trials, performed 6 days later (6‐day RAM). Two comparison conditions were included: (i) repeated locomotor training on a treadmill (TM); (ii) the same RAM training, except for the use of a longer (30 days instead of six) retention interval (30‐day RAM). Although all RAM groups displayed similar levels of performance at the end of the experiment, immediately before the mice were killed, significant between‐group differences in brain activation were observed. I

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Author

Khalid Touzani; Aline Marighetto; Robert Jaffard

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2003

Language

EN

Field

Neuroscience (Life Sciences)