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Transforming Potential of a Retrovirus Isolated from Lung Carcinoma of Sheep by N. Safran; A. Zimber; S. G. Irving; K. Perk is a Medicine article available to read on EtoBox.

What is Transforming Potential of a Retrovirus Isolated from Lung Carcinoma of Sheep about?

## Abstract A retrovirus isolated from experimentally induced sheep lung carcinoma (SPCTV) was propagated in chronically infected Himalayan tahr ovarian cells and in normal sheep lung cells. Follow‐up of infection of the cells with SPCTV showed the appearance of syncytium, plaque formation, partial recovery and the establishment of a chronic infection. Virus‐associated reverse transcriptase activity in the medium fluctuated but remained at a constantly high level at the stage of chronic infection. Stages of type‐C virus morphogenesis were demonstrated by electron microscopy. The viral genome was detected in both the nucleus and cytoplasm by __in situ__ hybridization. Chronically infected cells formed colonies when plated in soft agar. Following subcutaneous inoculation of chronically infected cells (of fibroblast origin) into nude mice, lymphoid tumors developed at the site of inoculation and in vital organs.

Who reads Transforming Potential of a Retrovirus Isolated from Lung Carcinoma of Sheep?

Author

N. Safran; A. Zimber; S. G. Irving; K. Perk

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1985

Language

EN

Field

Medicine (Health Sciences)