About this document
Biphasic Model for Drug Release in Hydrogels by Cedie Macalisang is a document available to read on EtoBox.
The document presents a mathematical model to describe the release of polymer-drug conjugates from poly(vinyl alcohol) hydrogels. The model is tested using fluorescein and fluorescein-dextran of different molecular weights encapsulated in PVA hydrogels. A one-coefficient diffusion model fits the release of small molecules well but a two-coefficient model better fits the release of larger macromolecules, suggesting hydrogels have dense and loose areas that influence diffusion differently. The accurate model
- Author
- Cedie Macalisang
- Language
- EN