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Exercise-Induced Adaptations to the Mouse Striatal Adenosine System by Bauer, Ella E.; Buhr, Trevor J.; Reed, Carter H.; Clark, Peter J. is a Neuroscience article available to read on EtoBox.

What is Exercise-Induced Adaptations to the Mouse Striatal Adenosine System about?

Adenosine acts as a key regulator of striatum activity, in part, through the antagonistic modulation of dopamine activity. Exercise can increase adenosine activity in the brain, which may impair dopaminergic functions in the striatum. Therefore, long-term repeated bouts of exercise may subsequently generate plasticity in striatal adenosine systems in a manner that promotes dopaminergic activity. This study investigated the effects of long-term voluntary wheel running on adenosine 1 (A~1~R), adenosine 2A (A~2A~R), dopamine 1 (D~1~R), and dopamine 2 (D~2~R) receptor protein expression in adult mouse dorsal and ventral striatum structures using immunohistochemistry. In addition, equilibrative nucleoside transporter 1 (ENT1) protein expression was examined after wheel running, as ENT1 regulates the bidirectional flux of adenosine between intra- and extracellular space. The results suggest that eight weeks of running wheel access spared age-related increases of A~1~R and A~2A~R protein concentrations across the dorsal and ventral striatal structures. Wheel running mildly reduced ENT1 protein levels in ventral striatum subregions. Moreover, wheel running mildly increased D~2~R protein de

Who reads Exercise-Induced Adaptations to the Mouse Striatal Adenosine System?

Author

Bauer, Ella E.; Buhr, Trevor J.; Reed, Carter H.; Clark, Peter J.

Publisher

Hindawi Publishing Corporation; Hindawi Limited; Walter de Gruyter GmbH; London: Hindawi, [1998]- (ISSN 0792-8483)

Published

2020

Language

EN

Field

Neuroscience (Life Sciences)