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Can I read Towards Fixed Dosing of Tocilizumab in ICU-Admitted COVID-19 Patients: Results of an Observational Population Pharmacokinetic and Descriptive Pharmacodynamic Study on EtoBox?
Towards Fixed Dosing of Tocilizumab in ICU-Admitted COVID-19 Patients: Results of an Observational Population Pharmacokinetic and Descriptive Pharmacodynamic Study by Dirk Jan A. R. Moes; David J. van Westerloo; Sandra M. Arend; Jesse J. Swen; Annick de Vries; Henk-Jan Guchelaar; Simone A. Joosten; Mark G. J. de Boer; Teun van Gelder; Judith van Paassen is a Medicine article available to read on EtoBox.
What is Towards Fixed Dosing of Tocilizumab in ICU-Admitted COVID-19 Patients: Results of an Observational Population Pharmacokinetic and Descriptive Pharmacodynamic Study about?
## Background and objective: In the randomized controlled trial remap-cap, it was shown that next to dexamethasone, the interleukin (il)-6 receptor antagonist tocilizumab improves outcome, including survival in intensive care unit (icu)-admitted coronavirus disease 2019 (covid)-19 patients. therefore tocilizumab has been added to many covid-19 treatment guidelines. because obesity is a risk factor for the development of severe covid-19, concerns have been raised about overtreatment, as well as undertreatment, through weight-based dosing of tocilizumab. the currently applied dose of 8 mg/kg is based on the use of this drug for other indications, however it has not formally been investigated for covid-19. in this study, the pharmacokinetics and pharmacodynamics of tocilizumab were investigated in icu-admitted covid-19 patients. ## Methods: This was an open-label, single-centre, observational population pharmacokinetic and descriptive pharmacodynamic evaluation study. enrolled patients, with polymerase chain reaction-confirmed covid-19 were admitted to the icu for mechanical ventilation or high flow nasal canula oxygen support. all patients were 18 years of age or older and received i
Who reads Towards Fixed Dosing of Tocilizumab in ICU-Admitted COVID-19 Patients: Results of an Observational Population Pharmacokinetic and Descriptive Pharmacodynamic Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dirk Jan A. R. Moes; David J. van Westerloo; Sandra M. Arend; Jesse J. Swen; Annick de Vries; Henk-Jan Guchelaar; Simone A. Joosten; Mark G. J. de Boer; Teun van Gelder; Judith van Paassen
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)