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Drug metabolism is categorized into phase I (functionalization) and phase II (conjugation) reactions, with phase I introducing polar functional groups to enhance water solubility, while phase II forms conjugated products for easier excretion. The liver is the primary site for drug metabolism, where first-pass effect can significantly reduce oral bioavailability of certain drugs, and the intestinal mucosa also plays a role in drug metabolism. Cytochrome P450 monooxygenases are crucial for oxidative biotransf
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