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The study investigates the insulin-sensitizing effects of glimepiride in obese insulin-resistant rats, demonstrating that it increases insulin sensitivity, GLUT4 protein expression, and glucose utilization in skeletal muscle, while also enhancing glycogen storage and insulin-induced GSK3 phosphorylation in the liver. Results indicate that glimepiride effectively improves glycaemic control through both pancreatic and extra-pancreatic mechanisms. This research highlights the potential of glimepiride as a dual
- Author
- 2020mt13286
- Language
- EN