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Phase II study evaluating consolidation whole abdominal intensity-modulated radiotherapy (IMRT) in patients with advanced ovarian cancer stage FIGO III - The OVAR-IMRT-02 Study by Nathalie Rochet; Meinhard Kieser; Florian Sterzing; Sonja Krause; Katja Lindel; Wolfgang Harms; Michael H Eichbaum; Andreas Schneeweiss; Christof Sohn; Juergen Debus is a Medicine article available to read on EtoBox.

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## Background The prognosis for patients with advanced FIGO stage III epithelial ovarian cancer remains poor despite the aggressive standard treatment, consisting of maximal cytoreductive surgery and platinum-based chemotherapy. The median time to recurrence is less than 2 years, with a 5-years survival rate of -20-25%. Recurrences of the disease occur mostly intraperitoneally. Ovarian cancer is a radiosensitive tumor, so that the use of whole abdominal radiotherapy (WAR) as a consolidation therapy would appear to be a logical strategy. WAR used to be the standard treatment after surgery before the chemotherapy era; however, it has been almost totally excluded from the treatment of ovarian cancer during the past decade because of its high toxicity. Modern intensity-modulated radiation therapy (IMRT) has the potential of sparing organs at risk like kidneys, liver, and bone marrow while still adequately covering the peritoneal cavity with a homogenous dose. Our previous phase I study showed for the first time the clinical feasibility of intensity-modulated WAR and pointed out promising results concerning treatment tolerance. The current phase-II study succeeds to the phase-I study to

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Author

Nathalie Rochet; Meinhard Kieser; Florian Sterzing; Sonja Krause; Katja Lindel; Wolfgang Harms; Michael H Eichbaum; Andreas Schneeweiss; Christof Sohn; Juergen Debus

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2001]-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2407)

Published

2011

Language

EN

ISBN

9781471240713

Field

Medicine (Health Sciences)