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Can I read Parvovirus B19 transmission by heat-treated clotting factor concentrates on EtoBox?
Parvovirus B19 transmission by heat-treated clotting factor concentrates by Johannes Blümel; Ivo Schmidt; Wolfgang Effenberger; Holger Seitz; Hannelore Willkommen; Hans Herrmann Brackmann; Johannes Löwer; Anna Maria Eis-Hübinger is a Medicine article available to read on EtoBox.
What is Parvovirus B19 transmission by heat-treated clotting factor concentrates about?
**BACKGROUND**: Human parvovirus B19 (B19) DNA can be frequently detected in plasma‐derived coagulation factor concentrates. The production of some clotting factor products includes heat treatment steps for virus inactivation, but the effectiveness of such steps for B19 inactivation is unclear. Moreover, detailed transmission case reports including DNA sequence analysis and quantification of B19 DNA from contaminated heat‐treated blood components have not been provided so far. Therefore, the correlation between B19 DNA in blood components and infectivity remains unclear. **STUDY DESIGN AND METHODS**: Asymptomatic B19 infections of two patients with hemophilia A were detected by anti‐B19 seroconversion after administration of B19‐contaminated heat‐treated clotting factors. The suitability of nucleic acid sequence analysis for confirmation of B19 transmission was investigated. Furthermore, the B19 DNA level in blood components was determined and the drug administration was reviewed to calculate the amount of inoculated B19 DNA. **RESULTS**: Both B19 transmissions from clotting factor products could be confirmed by identical nucleic acid sequences of virus DNA from patients and blood
Who reads Parvovirus B19 transmission by heat-treated clotting factor concentrates?
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- Author
- Johannes Blümel; Ivo Schmidt; Wolfgang Effenberger; Holger Seitz; Hannelore Willkommen; Hans Herrmann Brackmann; Johannes Löwer; Anna Maria Eis-Hübinger
- Publisher
- Elsevier Science; John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Elsevier; Elsevier BV; Wiley (ISSN 0372-1248)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)