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Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers by Ajay Goel; Christian N. Arnold; Pierfrancesco Tassone; Dong K. Chang; Donna Niedzwiecki; Jeannette M. Dowell; Linda Wasserman; Carolyn Compton; Robert J. Mayer; Monica M. Bertagnolli; C. Richard Boland is a Medicine article available to read on EtoBox.
What is Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers about?
## Abstract Runt domain transcription factors are important targets of TGF‐β superfamily proteins and play a crucial role in mammalian development. Three mammalian runt‐related genes, __RUNX1__, __RUNX2__ and __RUNX3__, have been described. __RUNX3__ has been shown to be a putative tumor suppressor gene localized to chromosome 1p36, a region showing frequent loss of heterozygosity events in colon, gastric, breast and ovarian cancers. Because of the important role of TGF‐β signaling in the human colon, we hypothesized that __RUNX3__ may serve as a key tumor suppressor in human colon cancers and colon cancer‐derived cell lines. We examined RUNX3 expression and the frequency of __RUNX3__ promoter hypermethylation in 17 colon cancer cell lines and 91 sporadic colorectal cancers. Semiquantitative analysis of __RUNX3__ transcripts was performed by RT‐PCR and __de novo__ methylation of the __RUNX3__ promoter was studied by a methylation‐specific PCR (MSP) assay. Nineteen of 91 informative tumors (21%) and 11 of 17 (65%) colon cancer cell lines exhibited hypermethylation of the __RUNX3__ promoter. Interestingly, __RUNX3__ promoter hypermethylation was more common in tumors exhibiting high
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- Author
- Ajay Goel; Christian N. Arnold; Pierfrancesco Tassone; Dong K. Chang; Donna Niedzwiecki; Jeannette M. Dowell; Linda Wasserman; Carolyn Compton; Robert J. Mayer; Monica M. Bertagnolli; C. Richard Boland
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)