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This systematic review synthesizes findings from 34 studies on the long-term effects of psychedelic drugs, primarily psilocybin, on human subjects. It documents enduring changes in personality, mental health, and well-being, often linked to mystical experiences and emotional breakthroughs, with minimal adverse effects reported. The review calls for future research to include larger, more diverse samples and standardized methodologies to better understand these long-term effects.

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