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Ureaplasma urealyticum and its association with chronic lung disease in Asian neonates by P Agarwal; Vs Rajadurai; Vk Pradeepkumar; Kw Tan is a Medicine article available to read on EtoBox.

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## Objective: The aim of the present prospective cohort study was to evaluate the relationship between lower respiratory tract colonization with ureaplasma urealyticum and development of chronic lung disease (cld) in a high-risk neonatal population. ## Methods: Prospective cohort study of preterm infants with a birthweight < 1,500 g needing mechanical ventilation within 24 h of birth in a tertiary care neonatal unit. endotracheal aspirates from these infants were cultured within 24 h for u. urealyticum and the rate of colonization was determined. the primary outcome measure was the incidence of cld at 28 days of life. ## Results: Of the 41 infants studied, 10 (24%) infants were colonized with u. urealyticum. the colonization rate was higher in babies < 1,000 g compared with babies weighing 1,000-1,500 g (p = 0.04). there was no significant difference between the colonized and non-colonized groups with regard to the antenatal use of steroids, maternal prolonged rupture of membranes, gestational age, birthweight, sex, respiratory distress syndrome, use of surfactant, patent ductus arteriosus and gastrooesophageal reflux. of the 37 survivors, 20 (54%) developed cld; eight infants (88.

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Author

P Agarwal; Vs Rajadurai; Vk Pradeepkumar; Kw Tan

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1034-4810)

Published

2000

Language

EN

Field

Medicine (Health Sciences)