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Strain-dependent Induction of Allergic Rhinitis Without Adjuvant in Mice by M Okano; DA Harn Jr; M Abe; M-M Wang; AR Satoskar; K Nishizaki; Y Masuda; M Okano; T Yoshino is a Medicine article available to read on EtoBox.

What is Strain-dependent Induction of Allergic Rhinitis Without Adjuvant in Mice about?

Background: To date, no murine models have been reported to show the induction of both antigen‐specific IgE and nasal eosinophilia, two of the major hallmarks of allergic rhinitis, after local sensitization in the absence of adjuvants, a phenomenon which reflects natural exposure. In this report, we attempted to establish a murine model representing an initiation of allergic rhinitis. Methods: BALB/c, CBA/J, and C57BL/6 mice were sensitized intranasally to __Schistosoma mansoni__ egg antigen (SEA) solely. After repeated sensitization, serum Ab titers, nasal eosinophilia, and cytokine production by nasal lymphocytes were determined. Results: BALB/c mice produced SEA‐specific IgE after repeated sensitization. High‐dose sensitization to SEA induced IgE production in CBA/J mice, while C57BL/6 mice did not show the production throughout the period observed, suggesting that IgE production was regulated genetically. BALB/c mice also exhibited nasal eosinophilia after the nasal challenge. In addition, nasal lymphocytes sensitized with SEA intranasally produced significant amount of IL‐5 __in vitro__. Conclusions: These results suggest that intranasal sensitization with SEA in the absence o

Who reads Strain-dependent Induction of Allergic Rhinitis Without Adjuvant in Mice?

Author

M Okano; DA Harn Jr; M Abe; M-M Wang; AR Satoskar; K Nishizaki; Y Masuda; M Okano; T Yoshino

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0105-4538)

Published

1999

Language

EN

Field

Medicine (Health Sciences)