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Efficacy of the World Health Organization analgesic ladder in the paclitaxel-induced pain syndrome in rats by Kelly de Vargas Pinheiro; Indiara Brusco; Bruna dos Santos Hausen; Rafael Noal Moresco; Flávia K. Rigo; Sara Marchesan Oliveira; Juliano Ferreira is a Medicine article available to read on EtoBox.
What is Efficacy of the World Health Organization analgesic ladder in the paclitaxel-induced pain syndrome in rats about?
Paclitaxel use in cancer treatment is limited by a painful syndrome that has no effective treatment. Despite new therapies, drugs of the World Health Organization (WHO) analgesic ladder remain a useful therapeutic tool for cancer pain relief. Since cancer pain is caused by both tumor and chemotherapy, we assessed the efficacy of drugs from the WHO analgesic ladder for cancer pain relief in a paclitaxel-induced pain syndrome (P-IPS) model. P-IPS was induced in rats by one or four injections of paclitaxel on alternate days. The acute and chronic phases were assessed 24 h and 15 days after the first paclitaxel injection, respectively. The mechanical allodynia was evaluated after (step 1 of the ladder) paracetamol, (step 2) codeine alone or plus paracetamol and (step 3) morphine treatment in the acute or chronic phase of P-IPS. Paracetamol, codeine and morphine were equally efficacious in reducing the acute phase of the P-IPS. Codeine plus paracetamol had similar efficacy and potency when administered together in the acute phase of the P-IPS, but produced a longer-lasting effect than when separately managed. Moreover, paracetamol, codeine and morphine partially reduced the chronic phas
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- Author
- Kelly de Vargas Pinheiro; Indiara Brusco; Bruna dos Santos Hausen; Rafael Noal Moresco; Flávia K. Rigo; Sara Marchesan Oliveira; Juliano Ferreira
- Publisher
- Springer; Springer-Verlag; Birkhauser Verlag; Springer Science and Business Media LLC (ISSN 0925-4692)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Life Sciences)