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STAT1-mediated Bim expression promotes the apoptosis of retinal pericytes under high glucose conditions by Shin, E S; Huang, Q; Gurel, Z; Palenski, T L; Zaitoun, I; Sorenson, C M; Sheibani, N is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is STAT1-mediated Bim expression promotes the apoptosis of retinal pericytes under high glucose conditions about?
Hyperglycemia impacts different vascular cell functions and promotes the development and progression of various vasculopathies including diabetic retinopathy. Although the increased rate of apoptosis in pericytes (PCs) has been linked to increased oxidative stress and activation of protein kinase C-__δ__ (PKC-__δ__) and SHP-1 (Src homology region 2 domain-containing phosphatase-1) tyrosine phosphatase during diabetes, the detailed mechanisms require further elucidation. Here we show that the rate of apoptosis and expression of proapoptotic protein Bim were increased in the retinal PCs of diabetic Akita/+ mice and mouse retinal PCs cultured under high glucose conditions. Increased Bim expression in retinal PCs under high glucose conditions required the sustained activation of signal transducer and activator of transcription 1 (STAT1) through production of inflammatory cytokines. PCs cultured under high glucose conditions also exhibited increased oxidative stress and diminished migration. Inhibition of oxidative stress, PKC-__δ__ or Rho-associated protein kinase I/II was sufficient to protect PCs against apoptosis under high glucose conditions. Furthermore, PCs deficient in Bim expre
Who reads STAT1-mediated Bim expression promotes the apoptosis of retinal pericytes under high glucose conditions?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Shin, E S; Huang, Q; Gurel, Z; Palenski, T L; Zaitoun, I; Sorenson, C M; Sheibani, N
- Publisher
- Nature Publishing Group; Springer Science and Business Media LLC; London: Nature Publishing Group, 2001- (ISSN 2041-4889)
- Published
- 2014
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)