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This document summarizes a review article about the impact of activating mutations in the STAT3 gene on human growth. STAT3 is a transcription factor involved in cell growth and immunity. Germline mutations that lead to STAT3 hyperactivation cause early-onset multiorgan autoimmunity, lymphoproliferation, infections, and short stature in humans. While the immune alterations of these STAT3 mutations have been studied extensively, less is known about their effects on growth. The review discusses current knowle

Author

mgutierrez.cedie

Language

EN