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Altered Redox Status May Contribute to Aberrant Folliculogenesis and Poor Reproductive Outcomes in Women with Polycystic Ovary Syndrome by Aalaap Naigaonkar; Roshan Dadachanji; Indira Hinduja; Srabani Mukherjee is a Medicine article available to read on EtoBox.

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## Background: Women with polycystic ovary syndrome (pcos) are often infertile and opt for artificial reproductive techniques (art) to conceive. disrupted pro-/antioxidant balance in oocyte microenvironment may contribute towards sub-optimal oocyte/embryo quality and poor art outcome in them. ## Methods: Activities/levels of redox markers and their transcript expression were investigated in follicular fluid and granulosa cells respectively, in women with pcos (n = 71) and controls (n = 50) undergoing in vitro fertilization (ivf). correlation analysis of redox markers and ivf parameters was performed. ## Results: Activities of superoxide dismutase, glutathione reductase, glutathione peroxidase, and paraoxonase1 were significantly lower in follicular fluid of pcos women than in controls. levels of lipid peroxidation, oxidative protein modification, and oxidized glutathione were higher, whereas those of total antioxidant capacity, total thiols, and reduced glutathione were lower in follicular fluid of pcos women than in controls. further, comparison of redox markers based on insulin resistance and bmi status of study participants showed similar trends, indicating that pcos pathophysio

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Author

Aalaap Naigaonkar; Roshan Dadachanji; Indira Hinduja; Srabani Mukherjee

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)