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CD56+ T cells inhibit hepatitis C virus replication in human hepatocytes by Li Ye; Xu Wang; Shihong Wang; Yanjian Wang; Li Song; Wei Hou; Lin Zhou; He Li; Wenzhe Ho is a Medicine article available to read on EtoBox.

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CD56 ؉ T cells are abundant in liver and play an important role in defense against viral infections. However, the role of CD56 ؉ T cells in control of hepatitis C virus (HCV) infection remains to be determined. We investigated the noncytolytic anti-HCV activity of primary CD56 ؉ T cells in human hepatocytes. When HCV Japanese fulminant hepatitis-1 (JFH-1)-infected hepatocytes were co-cultured with CD56 ؉ T cells or incubated in media conditioned with CD56 ؉ T cell culture supernatants (SN), HCV infectivity and replication were significantly inhibited. The antibodies to interferon (IFN)-␥ or IFN-␥ receptor could largely block CD56 ؉ T cell-mediated anti-HCV activity. Investigation of mechanism(s) responsible for CD56 ؉ T cell-mediated noncytolytic anti-HCV activity showed that CD56 ؉ T SN activated the multiple elements of janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway and enhanced the expression of IFN regulatory factors (IRFs) 1, 3, 7, 8, and 9, resulting in the induction of endogenous IFN-␣/␤ expression in hepatocytes. Moreover, CD56 ؉ T SN treatment inhibited the expression of HCV-supportive micro RNA (miRNA)-122 and enhanced the levels of anti-

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Author

Li Ye; Xu Wang; Shihong Wang; Yanjian Wang; Li Song; Wei Hou; Lin Zhou; He Li; Wenzhe Ho

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2008

Language

EN

Field

Medicine (Health Sciences)