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The Segregation of a Translocation T(1;4) in Two Male Carriers Heterozygous for the Translocation by A. M. Estop; F. Levinson; K. Cieply; V. Vankirk is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The Segregation of a Translocation T(1;4) in Two Male Carriers Heterozygous for the Translocation about?

We examined the meiotic segregation pattern of a t(1;4)(p36.2;q31.3) reciprocal translocation in two male cousins heterozygous for the translocation. The wife of subject 1 had four recognized spontaneous abortions and two carrier daughters, and the wife of subject 2 had three recognized spontaneous abortions and no liveborn children. The results showed that subject 1 had an imbalance rate of 54% and subject 2 had an imbalance rate of 61% with respect to the translocation. This was not statistically different (P = 0.3174) and the 95% confidence intervals overlapped for each segregation type. The sex ratio of X-and Y-bearing sperm was not statistically different than the expected 50%. The rate of structural abnormalities was 11.3% in subject 1 and 17.8% in subject 2. Both of these values were above the range of control subjects in our lab, but only subject 2's value fell outside the 95% confidence interval for the control population.

Who reads The Segregation of a Translocation T(1;4) in Two Male Carriers Heterozygous for the Translocation?

Author

A. M. Estop; F. Levinson; K. Cieply; V. Vankirk

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0340-6717)

Published

1992

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)