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P930Inflammatory leukocyte phenotypes are associated with increased mortality after transfemoral transcatheter aortic valve implantation by Hoffmann, J; Mas-Peiro, S; Boeckling, F; Rasper, T; Berkowitsch, A; Fichtlscherer, S; Dimmeler, S; Zeiher, A M; Vasa-Nicotera, M is a Medicine article available to read on EtoBox.

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Abstract Background Systemic inflammatory response syndrome (SIRS) was shown to be a strong predictor of mortality in patients undergoing transcatheter aortic valve implantation (TAVI). However, given the rather non-specific nature of the SIRS criteria and their limited applicability in the modern era of TAVI, including lower periprocedural complication rates and shorter hospitalization periods in experienced competence centers, there is a need for defining novel prognostic inflammatory signatures for improved patient risk stratification. Thus, the objective of the present study was to characterize and assess the prognostic relevance of circulating leukocyte subsets, including phenotypical heterogeneity of monocytes and effector T cells, before and at various times after transfemoral TAVI. Methods and results 129 consecutive patients (59% male, mean age 82.3±5.6 years) with severe symptomatic aortic stenosis (Pmean 44.2±17mmHg), and high or prohibitive operative risk (mean EuroSCORE II 5.9; STS score 4.1) admitted to our clinic for TAVI were included into the study. Peripheral blood samples were obtained pre-procedurally (baseline, BL), directly after the intervention, and at 24h a

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Author

Hoffmann, J; Mas-Peiro, S; Boeckling, F; Rasper, T; Berkowitsch, A; Fichtlscherer, S; Dimmeler, S; Zeiher, A M; Vasa-Nicotera, M

Publisher

Oxford University Press; Oxford University Press (OUP); Elsevier BV (ISSN 0195-668X)

Published

2019

Language

EN

Field

Medicine (Health Sciences)