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Vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and thrombospondin-1 (TSP-1) expression in urothelial carcinomas by Gamze Donmez; Yurdanur Sullu; Sancar Baris; Levent Yildiz; Oguz Aydin; Filiz Karagoz; Bedri Kandemir is a Medicine article available to read on EtoBox.

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Angiogenesis is a multistep process that depends on the balance of proangiogenic factors and inhibitors as well as on interactions with the extracellular matrix. We examined the immunohistochemical expression of the defining angiogenic agents, vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9), and the antiangiogenic agent thrombospondin-1 (TSP-1) in 131 patients with urethelial carcinoma and correlated their expression levels with clinicopathological parameters. VEGF and MMP-9 expression was higher in high-grade tumors than in low-grade tumors (p 1⁄4 0.000 and p 1⁄4 0.001, respectively), whereas the reverse was true for TSP-1 (p 1⁄4 0.000). VEGF and MMP-9 expression was higher in deeper tumors compared to superficial tumors and in invasive tumors compared to non-invasive tumors (p 1⁄4 0.001 and p 1⁄4 0.001, respectively), while TSP-1 was lower (p 1⁄4 0.000). We could differentiate 22 of 41 muscle-invasive (T2) cases as superficial (T2a; n 1⁄4 7) or deep (T2b; n 1⁄4 15), but no difference was found between them regarding VEGF, MMP-9, or TSP-1 expression (p 1⁄4 0.783, p 1⁄4 0.289, and p 1⁄4 0.783, respectively). There was a positive correlation between

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Author

Gamze Donmez; Yurdanur Sullu; Sancar Baris; Levent Yildiz; Oguz Aydin; Filiz Karagoz; Bedri Kandemir

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0344-0338)

Published

2009

Language

EN

Field

Medicine (Health Sciences)