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Antiviral properties of cobalt(III)-complexes by James B. Delehanty; Jason E. Bongard; Dzung C. Thach; D. Andrew Knight; Thomas E. Hickey; Eddie L. Chang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Antiviral properties of cobalt(III)-complexes about?

We have investigated the potential antiviral activity of three cobalt(III) compounds. Two compounds, Co(III)-cyclenmethylbenzoic acid and its methyl ester derivative, are based on the macrocyclic chelator, cyclen, and were synthesized in our laboratory. Both compounds have been shown to bind tightly to nucleic acids and to hydrolyze phosphodiester bonds. However, neither compound exhibited any significant antiviral activity in an in vitro model of Sindbis virus replication. In contrast, a third compound, Co(III)hexammine, significantly inhibited Sindbis virus replication in baby hamster kidney (BHK) cells in a doseand time-dependent manner. In plaque assays, the incubation of Co(III)hexammine with Sindbis virus resulted in a dose-dependent decrease in virus replication when measured at both 24 and 48-h post-infection. Over the concentration range of 0-5 mM Co(III)hexammine, the IC 50 for the inhibition of viral replication was determined to be 0.10 ± 0.04 mM at 48 h. Additionally, when BHK cell monolayers were pretreated with Co(III)hexammine for 6 h prior to Sindbis infection, optimal cellular morphology and plasma membrane integrity were observed at 0.6-1.2 mM Co(III)hexammine. A

Who reads Antiviral properties of cobalt(III)-complexes?

Author

James B. Delehanty; Jason E. Bongard; Dzung C. Thach; D. Andrew Knight; Thomas E. Hickey; Eddie L. Chang

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)