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Can I read Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study II on EtoBox?
Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study II by Karestan C Koenen; Immaculata De Vivo; Janet Rich-Edwards; Jordan W Smoller; Rosalind J Wright; Shaun M Purcell is a Psychology article available to read on EtoBox.
What is Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study II about?
## Background: One in nine american women will meet criteria for the diagnosis of posttraumatic stress disorder (ptsd) in their lifetime. although twin studies suggest genetic influences account for substantial variance in ptsd risk, little progress has been made in identifying variants in specific genes that influence liability to this common, debilitating disorder. ## Methods and design: We are using the unique resource of the nurses health study ii, a prospective epidemiologic cohort of 68,518 women, to conduct what promises to be the largest candidate gene association study of ptsd to date. the entire cohort will be screened for trauma exposure and ptsd; 3,000 women will be selected for ptsd diagnostic interviews based on the screening data. our nested case-control study will genotype 1000 women who developed ptsd following a history of trauma exposure; 1000 controls will be selected from women who experienced similar traumas but did not develop ptsd.the primary aim of this study is to detect genetic variants that predict the development of ptsd following trauma. we posit inherited vulnerability to ptsd is mediated by genetic variation in three specific neurobiological systems
Who reads Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study II?
It is typically read by researchers, students, and practitioners in Psychology.
- Author
- Karestan C Koenen; Immaculata De Vivo; Janet Rich-Edwards; Jordan W Smoller; Rosalind J Wright; Shaun M Purcell
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-244X)
- Published
- 2009
- Language
- EN
- Field
- Psychology (Social Sciences)