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Can I read Development And Validation Of Prediction Models For The Risk Of Total Knee Replacement Using Data From Multi-center Cohort Studies on EtoBox?
Development And Validation Of Prediction Models For The Risk Of Total Knee Replacement Using Data From Multi-center Cohort Studies by Q. Liu; H. Chu; M.P. LaValley; D.J. Hunter; H. Zhang; L. Tao; S. Zhan; Y. Zhang; J. Lin is a Medicine article available to read on EtoBox.
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hypothyroidism and NASS incidence, treated hypothyroidism was significantly associated with increased 8-year risk for radiographic KOA incidence (hazard ratio, 95% confidence interval (95%CI): 1.5, 1.05-2.15). (Table )Mediation analysis showed that a decrease in quadriceps CSA partially mediated increased KOA incidence risk in patients with treated hypothyroidism. ( Table )Moreover, results were not sensitive to the use of PS-matching or changing selection criteria of hypothyroid patients. Conclusions: Levothyroxine users, as a proxy indicator of clinically overt hypothyroidism, are at risk of increased quadriceps atrophy, but not adiposity. In addition, these participants may also have an increased risk of radiographic KOA incidence risk, which is partially mediated through increased quadriceps atrophy associated with treated hypothyroidism.
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It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Q. Liu; H. Chu; M.P. LaValley; D.J. Hunter; H. Zhang; L. Tao; S. Zhan; Y. Zhang; J. Lin
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)