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Nucleophilic Substitution in Aryl Halides by Ananda Vijayasarathy is a document available to read on EtoBox.

Nucleophilic aromatic substitution reactions involve an aromatic halide reacting with a nucleophile to replace the halide. [1] Electron withdrawing groups ortho or para to the site of attack activate the aryl halide by stabilizing the intermediate carbanion. [2] In the absence of such groups, the reaction occurs through an elimination/addition mechanism rather than SN1 or SN2, forming the unstable intermediate benzyne. [3] Experimental evidence shows this leads to a 50:50 mixture of products, distinguishing

Author

Ananda Vijayasarathy

Language

EN