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Can I read Repetitive Diacetyl Vapor Exposure Promotes Ubiquitin Proteasome Stress and Precedes Bronchiolitis Obliterans Pathology on EtoBox?
Repetitive Diacetyl Vapor Exposure Promotes Ubiquitin Proteasome Stress and Precedes Bronchiolitis Obliterans Pathology by Juan Wang; So-Young Kim; Emma House; Heather M. Olson; Carl J. Johnston; David Chalupa; Eric Hernady; Thomas J. Mariani; Gérémy Clair; Charles Ansong; Wei-Jun Qian; Jacob N. Finkelstein; Matthew D. McGraw is a Environmental Science article available to read on EtoBox.
What is Repetitive Diacetyl Vapor Exposure Promotes Ubiquitin Proteasome Stress and Precedes Bronchiolitis Obliterans Pathology about?
Bronchiolitis obliterans (BO) is a devastating lung disease seen commonly after lung transplant, following severe respiratory tract infection or chemical inhalation exposure. Diacetyl (DA; 2,3-butanedione) is a highly reactive alpha-diketone known to cause BO when inhaled, however, the mechanisms of how inhalation exposure leads to BO development remains poorly understood. In the current work, we combined two clinically relevant models for studying the pathogenesis of DA-induced BO: (1) an in vivo rat model of repetitive DA vapor exposures with recovery and (2) an in vitro model of primary human airway epithelial cells exposed to pure DA vapors. Rats exposed to 5 consecutive days 200 parts-per-million DA 6 h per day had worsening survival, persistent hypoxemia, poor weight gain, and histologic evidence of BO 14 days after DA exposure cessation. At the end of exposure, increased expression of the ubiquitin stress protein ubiquitin-C accumulated within DA-exposed rat lung homogenates and localized primarily to the airway epithelium, the primary site of BO development. Lung proteasome activity increased concurrently with ubiquitin-C expression after DA exposure, supportive of signific
Who reads Repetitive Diacetyl Vapor Exposure Promotes Ubiquitin Proteasome Stress and Precedes Bronchiolitis Obliterans Pathology?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Juan Wang; So-Young Kim; Emma House; Heather M. Olson; Carl J. Johnston; David Chalupa; Eric Hernady; Thomas J. Mariani; Gérémy Clair; Charles Ansong; Wei-Jun Qian; Jacob N. Finkelstein; Matthew D. McGraw
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Environmental Science (Life Sciences)