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The arrest gene is required for germline cyst formation during Drosophila oogenesis by Michael J. Parisi; Wei Deng; Zhong Wang; Haifan Lin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Summary: In __Drosophila__, oogenesis is initiated when a germline stem cell produces a differentiating daughter cell called the cystoblast. The cystoblast undergoes four rounds of synchronous divisions with incomplete cytokinesis to generate a syncytial cyst of 16 interconnected cystocytes, in which one cystocyte differentiates into an oocyte. Strong mutations of the __arrest__ (__aret__) gene disrupt cyst formation and cause the production of clusters of ill‐differentiated germline cells that retain cellular and molecular characteristics of cystoblasts. These mutant germ cells express high levels of BAM‐C and SXL proteins in the cytoplasm but do not accumulate markers for advanced cystocytes or differentiating oocytes, such as the nuclear localization of SXL or the accumulation of __osk__ mRNA, __orb__ mRNA, and cytoplasmic dynein. However, the mutant germ cells do not contain spectrosomes, the cytoplasmic structure that objectifies the divisional asymmetry of the cystoblast. The __aret__ mutant germ cells undergo active mitosis with complete cytokinesis. Their mitosis is accompanied by massive necrosis, so that the number of germ cells in a stem cell‐derived cluster

Who reads The arrest gene is required for germline cyst formation during Drosophila oogenesis?

Author

Michael J. Parisi; Wei Deng; Zhong Wang; Haifan Lin

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1526-954X)

Published

2001

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)