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Survival and Prognostic Factors in Surgically Treated Brain Metastases by Kavouridis, Vasileios K.; Harary, Maya; Hulsbergen, Alexander F. C.; Lo, Yu T.; Reardon, David A.; Aizer, Ayal A.; Iorgulescu, J. Bryan; Smith, Timothy R. is a Medicine article available to read on EtoBox.

What is Survival and Prognostic Factors in Surgically Treated Brain Metastases about?

## Purpose: While surgery and radiation remain the mainstays of therapy for all patients with brain metastases (bm), the management is moving to a more individualized approach based on the underlying tumor. we sought to identify prognostic factors of both intracranial progression (ic-pfs) and overall survival (os) in a surgical cohort. ## Methods: We retrospectively reviewed the records of 1015 patients treated surgically for bm at brigham and women's hospital (2007-2017). kaplan-meier curves were used for os and ic-pfs and cox proportional hazards models were built to assess for predictive factors. ## Results: Common origins were lung (43.9%), breast (14.4%), and melanoma (13.8%). median os for the cohort was 15.4 months (95% confidence interval [95%ci] 14.1-17.1). breast cancer (22.1 months, 95%ci 17.8-30.3) and colorectal cancer (10.6 months, 95%ci 7.2-15.4) had the longest and shortest os, respectively. on multivariable cox regression, significant prognostic factors of shorter os were age (hr 1.01, 95%ci 1.01-1.02), number of lesions (hr 1.56, 95%ci 1.28-1.89), extracranial spread at bm diagnosis (hr 1.26, 95%ci 1.05-1.52), and kps (hr 0.98, 95%ci 0.98-0.99). regarding molecula

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Author
Kavouridis, Vasileios K.; Harary, Maya; Hulsbergen, Alexander F. C.; Lo, Yu T.; Reardon, David A.; Aizer, Ayal A.; Iorgulescu, J. Bryan; Smith, Timothy R.
Publisher
Springer US; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0167-594X)
Published
2019
Language
EN
Field
Medicine (Health Sciences)

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