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Synthesis of I‐131 labelled 4‐iodophenylacetic acid by Zoltan Szucs; Mike Sathekge; Biljana Marjanovic‐Painter; Judith Wagener; Thato Sello; Carl Wagener; Jan Rijn Zeevaart is a Medicine article available to read on EtoBox.
What is Synthesis of I‐131 labelled 4‐iodophenylacetic acid about?
## Abstract Phenylacetate has been reported to have a potent anti‐proliferative and anti‐differentiating effect in haematological malignancies and in solid tumours at non‐toxic concentrations. This study is a preliminary investigation into the potential of 4‐iodophenylacetic acid radiolabelled by ^131^I as a radiopharmaceutical equivalent. The radiolabelling by isotope exchange gave a radiochemical yield of 53±6%, and a radiochemical purity of 97.8±1.2% as qualified by HPLC. The product contained 4% ester by‐product and is suitable for studies in animals. Copyright © 2010 John Wiley & Sons, Ltd.
Who reads Synthesis of I‐131 labelled 4‐iodophenylacetic acid?
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- Author
- Zoltan Szucs; Mike Sathekge; Biljana Marjanovic‐Painter; Judith Wagener; Thato Sello; Carl Wagener; Jan Rijn Zeevaart
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Life Sciences)