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Preparation and Properties of Inhalable Nanocomposite Particles for Treatment of Lung Cancer by Keishiro Tomoda; Takumi Ohkoshi; Keiji Hirota; Ganeshchandra S. Sonavane; Takehisa Nakajima; Hiroshi Terada; Masahito Komuro; Kenji Kitazato; Kimiko Makino is a Materials Science article available to read on EtoBox.
What is Preparation and Properties of Inhalable Nanocomposite Particles for Treatment of Lung Cancer about?
Nanoparticles have widely been studied in drug delivery research for targeting and controlled release. The aim of this article is application of nanoparticles as an inhalable agent for treatment of lung cancer. To deposit effectively deep the particles in the lungs, the PLGA nanoparticles loaded with the anticancer drug 6-{[2-(dimethylamino)ethyl]amino}-3-hydroxyl-7H-indeno[2,1-c]quinolin-7-one dihydrochloride (TAS-103) were prepared in the form of nanocomposite particles. The nanocomposite particles consist of the complex of drug-loaded nanoparticles and excipients. In this study, the anticancer effects of the nanocomposite particles against the lung cancer cell line A549. Also, the concentration of TAS-103 in blood and lungs were determined after administration of the nanocomposite particles by inhalation to rats. TAS-103-loaded PLGA nanoparticles were prepared with 5% and 10% of loading ratio by spray drying method with trehalose as an excipient. The 5% drug-loaded nanocomposite particles were more suitable for inhalable agent because of the sustained release of TAS-103 and higher FPF value. Cytotoxicity of nanocomposite particles against A549 cells was higher than that of free
Who reads Preparation and Properties of Inhalable Nanocomposite Particles for Treatment of Lung Cancer?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Keishiro Tomoda; Takumi Ohkoshi; Keiji Hirota; Ganeshchandra S. Sonavane; Takehisa Nakajima; Hiroshi Terada; Masahito Komuro; Kenji Kitazato; Kimiko Makino
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0927-7765)
- Published
- 2009
- Language
- EN
- Field
- Materials Science (Physical Sciences)