Can I read HEPARIN-INDUCED THROMBOCYTOPENIA IN DIALYSIS: The Pathophysiology of Immune-mediated Heparin-induced Thrombocytopenia on EtoBox?

HEPARIN-INDUCED THROMBOCYTOPENIA IN DIALYSIS: The Pathophysiology of Immune-mediated Heparin-induced Thrombocytopenia by Robert F. Reilly is a Medicine article available to read on EtoBox.

What is HEPARIN-INDUCED THROMBOCYTOPENIA IN DIALYSIS: The Pathophysiology of Immune-mediated Heparin-induced Thrombocytopenia about?

## Abstract Heparin‐induced thrombocytopenia (HIT) is an important side effect of heparin therapy associated with significant morbidity and mortality if unrecognized. The platelet count typically falls below 150,000/μl 5–14 days after heparin is started. Thrombosis is the major clinical complication. The diagnosis is confirmed with a variety of functional and antigenic assays. Heparin binds to PF4, resulting in a conformational change in the molecule that exposes neo‐epitopes that act as immunogens. Antibodies form against the heparin‐PF4 complex, the major target antigen. The IgG‐heparin‐PF4 immune complex binds either via its Fab domain to the platelet surface or via its Fc domain to the FcγIIA receptor on the surface of the platelet, resulting in further platelet activation. Continued release of PF4 from activated platelets leads to increasing PF4‐heparin complex formation, and a self‐propagating cycle of platelet consumption and generation of procoagulant platelet‐derived microparticles. Other procoagulant effects of the HIT antibody include endothelial cell damage, stimulation of platelet‐leukocyte aggregates, and release of tissue factor from monocytes.

Who reads HEPARIN-INDUCED THROMBOCYTOPENIA IN DIALYSIS: The Pathophysiology of Immune-mediated Heparin-induced Thrombocytopenia?

Author

Robert F. Reilly

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0894-0959)

Published

2003

Language

EN

Field

Medicine (Health Sciences)