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Intrinsic Functional Connectivity in Families Genetically Enriched for Social Anxiety Disorder – an Endophenotype Study by Janna Marie Bas-Hoogendam; Henk van Steenbergen; Kathrin Cohen Kadosh; P. Michiel Westenberg; Nic J.A. van der Wee is a Medicine article available to read on EtoBox.
What is Intrinsic Functional Connectivity in Families Genetically Enriched for Social Anxiety Disorder – an Endophenotype Study about?
## Background Social anxiety disorder (SAD) is a serious psychiatric condition with a high prevalence, and a typical onset during childhood/adolescence. The condition runs in families, but it is largely unknown which neurobiological characteristics transfer this genetic vulnerability (‘endophenotypes’). Using data from the Leiden Family Lab study on SAD, including two generations of families genetically enriched for SAD, we investigated whether social anxiety (SA) co-segregated with changes in intrinsic functional connectivity (iFC), and examined heritability. ## Methods Functional MRI data were acquired during resting-state in 109 individuals (56 males; mean age: 31·5, range 9·2-61·5 years). FSL's tool MELODIC was used to perform independent component analysis. Six networks of interest (default mode, dorsal attention, executive control, frontoparietal, limbic and salience) were identified at the group-level and used to generate subject-specific spatial maps. Voxel-wise regression models, with SA-level as predictor and voxel-wise iFC as candidate endophenotypes, were performed to investigate the association with SA, within masks of the networks of interest. Subsequently, heritabili
Who reads Intrinsic Functional Connectivity in Families Genetically Enriched for Social Anxiety Disorder – an Endophenotype Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Janna Marie Bas-Hoogendam; Henk van Steenbergen; Kathrin Cohen Kadosh; P. Michiel Westenberg; Nic J.A. van der Wee
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Life Sciences)