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miR-34-5p, encoded by Spodoptera frugiperda, participates in anti-baculovirus by regulating innate immunity in the insect host by Chen Wang; Xiaojun Guo; Yingqi Li; Jianzhen Zhang; Yuejun Fu is a Materials Science article available to read on EtoBox.
What is miR-34-5p, encoded by Spodoptera frugiperda, participates in anti-baculovirus by regulating innate immunity in the insect host about?
Spodoptera frugiperda is one of the significant migratory pests. Baculovirus, an insect-specific microbial insecticide, has been used to control pests. microRNA-34 (miR-34) regulates insect development and innate immunity to pathogens. This study explored the critical functions of miR-34-5p, encoded by S. frugiperda, in the anti-AcMNPV by targeting the JAK/STAT immune pathway. Integrating immune signal pathways analysis, developmental expression patterns, larval development, and genomic replication assay, we focused on the stat, a miR-34-5p target gene, and comprehensively revealed a novel mechanism of physiological and anti-virus function in S. frugiperda. miR-34-5p inhibited AcMNPV proliferation by targeting stat and provided an unfavorable environment for the virus by affecting the host genome replication and promoting the cell to undergo apoptosis. Moreover, stat silence suppressed viral and host genome replication, impaired viral proliferation by suppressing the transcript level of viral early gene ie1, ie2, and promoted apoptosis by affecting p35 expression. This study highlighted that the miR-34-5p target gene stat played physiological functions in the insect antiviral immun
Who reads miR-34-5p, encoded by Spodoptera frugiperda, participates in anti-baculovirus by regulating innate immunity in the insect host?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Chen Wang; Xiaojun Guo; Yingqi Li; Jianzhen Zhang; Yuejun Fu
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Materials Science (Physical Sciences)
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