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Can I read Delivering Crocetin across the Blood-Brain Barrier by Using Î3-Cyclodextrin to Treat Alzheimerâs Disease on EtoBox?
Delivering Crocetin across the Blood-Brain Barrier by Using Î3-Cyclodextrin to Treat Alzheimerâs Disease by Wong, Ka Hong; Xie, Yuning; Huang, Xiao; Kadota, Kazunori; Yao, Xin-Sheng; Yu, Yang; Chen, Xiaoyu; Lu, Aiping; Yang, Zhijun is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Delivering Crocetin across the Blood-Brain Barrier by Using Î3-Cyclodextrin to Treat Alzheimerâs Disease about?
Crocetin (CRT) has shown various neuroprotective effects such as antioxidant activities and the inhibition of amyloid β fibril formation, and thus is a potential therapeutic candidate for Alzheimer’s disease (AD). However, poor water solubility and bioavailability are the major obstacles in formulation development and pharmaceutical applications of CRT. In this study, a novel water-soluble CRT-γ-cyclodextrin inclusion complex suitable for intravenous injection was developed. The inclusion complex was nontoxic to normal neuroblastoma cells (N2a cells and SH-SY5Y cells) and AD model cells (7PA2 cells). Furthermore, it showed stronger ability to downregulate the expression of C-terminus fragments and level of amyloid β in 7PA2 cell line as compared to the CRT free drug. Both inclusion complex and CRT were able to prevent SH-SY5Y cell death from H~2~O~2~-induced toxicity. The pharmacokinetics and biodistribution studies showed that CRT-γ-cyclodextrin inclusion complex significantly increased the bioavailability of CRT and facilitated CRT crossing the blood-brain barrier to enter the brain. This data shows a water-soluble γ-cyclodextrin inclusion complex helped to deliver CRT across the
Who reads Delivering Crocetin across the Blood-Brain Barrier by Using Î3-Cyclodextrin to Treat Alzheimerâs Disease?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Wong, Ka Hong; Xie, Yuning; Huang, Xiao; Kadota, Kazunori; Yao, Xin-Sheng; Yu, Yang; Chen, Xiaoyu; Lu, Aiping; Yang, Zhijun
- Publisher
- Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)
- Published
- 2020
- Language
- EN
- ISBN
- 9784159802067
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)