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A Randomized Trial of Silymarin for the Treatment of Nonalcoholic Steatohepatitis by Chan Wah Kheong; Nik Raihan Nik Mustapha; Sanjiv Mahadeva is a Medicine article available to read on EtoBox.

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## Background & aims: Silymarin is a complex mixture of 6 major flavonolignans and other minor polyphenolic compounds derived from the milk thistle plant silybum marianum; it has shown antioxidant, anti-inflammatory and antifibrotic effects, and may be useful in patients with nonalcoholic fatty liver disease (nafld). we aimed to study the efficacy of silymarin in patients with nonalcoholic steatohepatitis (nash)-the more severe form of nafld. ## Methods: We performed a randomized, double-blind, placebo-controlled trial of consecutive adults with biopsy-proven nash and a nafld activity score (nas) of 4 or more at a tertiary care hospital in kuala lumpur, malaysia, from november 2012 through august 2014. patients were randomly assigned to groups given silymarin (700 mg; n = 49 patients) or placebo (n = 50 patients) 3 times daily for 48 weeks. after this 48-week period, liver biopsies were repeated. the primary efficacy outcome was a decrease of 30% or more in nas; findings from 48-week liver biopsies were compared with those from the baseline biopsy. secondary outcomes included changes in steatosis, lobular inflammation, hepatocyte ballooning, nas and fibrosis score, and anthropometr

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Author

Chan Wah Kheong; Nik Raihan Nik Mustapha; Sanjiv Mahadeva

Publisher

Elsevier BV

Published

2017

Language

EN

Field

Medicine (Health Sciences)