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The interactions of gallium with various buffers and chelating agents in aqueous solution: Gallium-71 and hydrogen-1 NMR studies by C.H.Francis Chang; T.Phil Pitner; Robert E. Lenkinski; Jerry D. Glickson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The interactions of gallium (Ga) with the ligands, EDTA, NTA, phosphate, lactate, MOPS, TRIS and HEPES are investigated using both "Ga and 'I-I nmr measurements\_ Both EDTA and NTA form strong comp!exes with gallium, which have a 1:l stoichiometry. In alkaline solution the tetrahedral Ga(OD)4-competes strongly with EDTA in complex formation. In the lactate complex, there are probably three lactates per gallium present. The phosphate complexes of gallium are difficult to characterize on the basis of this investigation. The buffers, MOPS, TRIS, and HEPES, do not interact with gallium significantly. The ability of the ligands to bind gallium correlates well with their ability to inhibit gallium incorporation by L1210 leukemic cells.

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Author

C.H.Francis Chang; T.Phil Pitner; Robert E. Lenkinski; Jerry D. Glickson

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0006-3061)

Published

1978

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)