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Increased Risk of Severe Cutaneous Adverse Reactions When Cladribine Is Used Together with Other Medications with a Propensity for Skin Reactions by Janice Haynes; Maria Jackson; Steven S. Smugar is a Medicine article available to read on EtoBox.

What is Increased Risk of Severe Cutaneous Adverse Reactions When Cladribine Is Used Together with Other Medications with a Propensity for Skin Reactions about?

we also sought to determine the effect of SID on all CADRs associated with cladribine.The Janssen GSD contains all adverse events (AE) received for cladribine and represents more than 77,000 treatment courses. The GSD was searched for all cases received cumulatively through 19 January 2021 involving cladribine as a suspect or suspect-interacting drug. For the analysis of SCARs, cases were identified by any reported Medical Dictionary for Regulatory Activities (MedDRA; v23.1) preferred term (PT) within the Standardized MedDRA Query (SMQ) Severe cutaneous adverse reaction (narrow). These terms include Acute generalized exanthematous pustulosis, Bullous hemorrhagic dermatosis, Cutaneous vasculitis, Dermatitis bullous, Dermatitis exfoliative, Dermatitis exfolatiative generalized, DRESS, Epidermal necrosis, Erythema multiforme, Erythrodermic atopic dermatitis, Exfoliative rash, Oculomucocutaneous syndrome, SJS-TEN overlap, Skin necrosis, SJS, Target skin lesion, TEN, and Toxic skin eruption. Valid cases from all sources (e.g. spontaneous post-marketing, clinical trial, etc.) and all reporters (i.e. healthcare professional and consumer) were included. Cases of AGEP, SJS, TEN, erythema mu

Who reads Increased Risk of Severe Cutaneous Adverse Reactions When Cladribine Is Used Together with Other Medications with a Propensity for Skin Reactions?

Author

Janice Haynes; Maria Jackson; Steven S. Smugar

Publisher

Informa UK Limited

Published

2022

Language

EN

Field

Medicine (Health Sciences)