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Bilateral High-frequency Noninvasive Peroneal Nerve Stimulation Evokes Tonic Leg Muscle Activation for Sleep-compatible Reduction of Restless Legs Syndrome Symptoms by Jonathan D. Charlesworth; Bahman Adlou; Haramandeep Singh; Mark J. Buchfuhrer is a Medicine article available to read on EtoBox.

What is Bilateral High-frequency Noninvasive Peroneal Nerve Stimulation Evokes Tonic Leg Muscle Activation for Sleep-compatible Reduction of Restless Legs Syndrome Symptoms about?

Study Objectives: Restless legs syndrome (RLS) is a prevalent sleep disorder with limited treatment options. Bilateral high-frequency noninvasive peroneal nerve stimulation (NPNS) reduces RLS symptoms. Here, we sought to characterize the mechanism of action for NPNS and identify predictors of treatment response. We hypothesized that, similar to voluntary leg movements, NPNS reduces RLS symptoms by activating leg muscles. Methods: For 20 adults with moderate-severe RLS, we tested this hypothesis by recording surface electromyography (EMG) from the tibialis anterior leg muscle while administering NPNS at varying amplitudes to determine the minimum NPNS amplitude that evoked EMG activity (motor threshold) and maximal NPNS amplitude that was not distracting (therapeutic intensity level). Afterwards, participants self-administered NPNS (at the therapeutic intensity level) and sham control for 14 days, each in randomized order. Efficacy was defined as International RLS Study Group Rating Scale (IRLS) score difference for NPNS compared with sham. Results: NPNS consistently activated leg muscles; NPNS evoked EMG activity at the therapeutic intensity level for 19 of 20 participants (mean TI

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Author

Jonathan D. Charlesworth; Bahman Adlou; Haramandeep Singh; Mark J. Buchfuhrer

Publisher

American Academy of Sleep Medicine (AASM)

Published

2023

Language

EN

Field

Medicine (Health Sciences)