Can I read HPC2/ELAC2 polymorphism associated with Japanese sporadic prostate cancer on EtoBox?

HPC2/ELAC2 polymorphism associated with Japanese sporadic prostate cancer by Akira Yokomizo; Hirofumi Koga; Naoko Kinukawa; Taiji Tsukamoto; Yoshihiko Hirao; Hideyuki Akaza; Mitsuru Mori; Seiji Naito is a Medicine article available to read on EtoBox.

What is HPC2/ELAC2 polymorphism associated with Japanese sporadic prostate cancer about?

## Abstract ## BACKGROUND __HPC2/ELAC2__ gene was identified by linkage analysis from familial prostate cancer (Pca) patients in USA. To determine the association of __HPC2/ELAC2__ gene with Japanese sporadic Pca, we performed a case‐control study focused on two missense polymorphisms. ## METHODS We genotyped the two polymorphic sites of Ser217Leu and Ala541Thr in sporadic Japanese Pca patients (n = 285) and matched controls (n = 233). Controls were unrelated Japanese outpatients who had no history of any cancer and normal PSA level (less than 4.0 ng/ml). Statistical analyses were performed by Mann–Whitney's U‐test, Fisher's exact test, and logistic regression analysis. ## RESULTS We observed a significantly higher frequency of the Thr allele at 541 polymorphic site in Pca patients (8.4%) compared to the control group (2.1%) (__P__ = 0.0030, Odds Ratio (OR) = 4.02, 95% CI = 1.50–10.8). However, this SNP does not correlate with clinical stage, PSA level, Gleason score of biopsies or age at diagnosis. No association was identified at Ser217Leu polymorphic site. ## CONCLUSIONS Our results indicate that Thr allele at 541 in HPC2/ELAC2 has strong significance in the predisposition of sp

Who reads HPC2/ELAC2 polymorphism associated with Japanese sporadic prostate cancer?

Author

Akira Yokomizo; Hirofumi Koga; Naoko Kinukawa; Taiji Tsukamoto; Yoshihiko Hirao; Hideyuki Akaza; Mitsuru Mori; Seiji Naito

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2004

Language

EN

Field

Medicine (Health Sciences)