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DNA methyltransferase 3a mediates developmental thermal plasticity by Loughland, Isabella (author);Little, Alexander (author);Seebacher, Frank (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is DNA methyltransferase 3a mediates developmental thermal plasticity about?

## Abstract ## Background Thermal plasticity is pivotal for evolution in changing climates and in mediating resilience to its potentially negative effects. The efficacy to respond to environmental change depends on underlying mechanisms. DNA methylation induced by DNA methyltransferase 3 enzymes in the germline or during early embryonic development may be correlated with responses to environmental change. This developmental plasticity can interact with reversible acclimation within adult organisms, which would increase the speed of response and could alleviate potential mismatches between parental or early embryonic environments and those experienced at later life stages. Our aim was to determine whether there is a causative relationship between DNMT3 enzyme and developmental thermal plasticity and whether either or both interact with short-term acclimation to alter fitness and thermal responses in zebrafish (Danio rerio). ## Results We developed a novel DNMT3a knock-out model to show that sequential knock-out of DNA methyltransferase 3a isoforms (DNMT3aa^−/−^and DNMT3aa^−/−^ab^−/−^) additively decreased survival and increased deformities when cold developmental temperatures in zeb

Who reads DNA methyltransferase 3a mediates developmental thermal plasticity?

Author

Loughland, Isabella (author);Little, Alexander (author);Seebacher, Frank (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)